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514 We and others have found the potential therapeutic benefits by PGC1 and TFEB upregulation in counteracting declined autophagy capacity and reduced proteostasis

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Glutamine, through conversion to glutamate and subsequently to -ketoglutarate (-KG), not only fuels the tricarboxylic acid (TCA) cycle for energy generation but also contributes carbon skeletons for lipid, carbohydrate, and nucleotide biosynthesis, thus sustaining the high metabolic demands of activated fibroblasts [8]